Research on variable ventilation bestowed with „Dräger Award for Intensive Care Medicine“

During the opening ceremony, Professor Benedikt Pannen, Chairperson of the ESA Scientific Programme Committee, together with Oliver Rosenthal, Head of Dräger Strategic Business Field Anesthesiology, presented the award to Professor Marcelo Gama de Abreu, representing his working group. “With the „Dräger Award for Intensive Care Medicine“, Dräger honors scientific endeavors and supports advances in the field of critical care medicine”, explained Rosenthal. The annual prize awards significant European research in the field of intensive care medicine and is given to an anesthetic or intensive care department rather than to any one research worker.

This year, the Dräger Prize subcommittee of the ESA awarded the prize to a working group that conducted the first laboratory research work showing that it is possible to improve protective mechanical ventilation beyond the current standard proposed by the ARDS Network (Acute Respiratory Distress Syndrome) and also improve a mechanical ventilation commonly known as “open lung approach”. “We found that in acute lung injury, variable ventilation in combination with different protective ventilation strategies improves respiratory function and reduces ventilator associated lung injury”, explains Professor Marcelo Gama de Abreu. The group conducted the first study showing that variable ventilation (breath-by-breath variation of tidal volumes) is able to attenuate lung histological damage and demonstrated that it does not increase gene expression or release of pro-inflammatory markers of lung injury.

As Chairman of the Dräger Prize Subcommittee, Dr. César Aldecoa Alvares Santullano, Department of Anaesthesiology and Intensive Care, Hospital Universitario Rio Hortega, Valladolid, Spain, stated that this paper was selected as it is an outstanding high-quality scientific study on the treatment of acute lung injury with results that play a leading role in influencing future clinical practice beyond current standards.


¹ Head of the working group: Prof. Marcelo Gama de Abreu; members: Peter M. Spieth, Alysson R. Carvalho, Paolo Pelosi, Catharina Hoehn, Christoph Meissner, Michael Kasper, Matthias Hübler, Matthias von Neindorff, Constanze Dassow, Martina Barrenschee, Stefan Uhlig, Thea Koch, at the Department of Anaesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden, Germany ² Spieth PM, Carvalho AR, Pelosi P, Höhn C, Meissner C, Kasper M, Hübler M, von Neindorff M, Dassow C, Barrenschee M, Uhlig S, Koch T, Gama de Abreu M (2009) Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. Am J Respir Crit Care Med 179:684–693